Hyperlipidemia

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Targets

Risk 10-year CAD Risk Recommendations Grade, LOE
High ≥20% Treatment targets:

Primary: LDL-C <2.0 mmol/L
Secondary: TC/HDL-C <4.0


Class I, level A
Class IIa, level A

Moderate 10% – 19% Treat when:

LDL-C ≥3.5 mmol/L or
TC/HDL-C ≥5.0


Class I, level A
Class I, level A

Low <10% Treat when:

LDL-C ≥5.0 mmol/L or
TC/HDL-C ≥6.0


Class IIa, level A
Class IIa, level A

Screening

  • M> 40; F >50 (or postmenopausal): Full lipid profile q1-3y
  • Children if FH of monogenic lipid disorder (familial hypercholesterolemia or chylomicronemia)
  • DM
  • Smoker
  • HTN
  • Waist circumference > 102cm (M); 88cm (F)
  • FH of premature CAD (M < 55; F < 65)
  • Manifestation of hyperlipidemia
  • Exertional chest discomfort, dyspnea, erectile dysfunction
  • Chronic kidney disease
  • Lupus
  • Evidence of Atherosclerosis