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Janeway Figure 8.5. L-Selectin and the mucinlike vascular addressins direct naive lymphocyte homing to lymphoid tissues. L-Selectin is expressed on naive T cells, which bind to sulfated sialyl-Lewisx moieties on the vascular addressins CD34 and GlyCAM-1 on high endothelial venules in order to enter lymph nodes. The relative importance of CD34 and GlyCAM-1 in this interaction is unclear. GlyCAM-1 is expressed exclusively on high endothelial venules but has no transmembrane region and it is unclear how it is attached to the membrane; CD34 has a transmembrane anchor and is expressed in appropriately glycosylated form only on high endothelial venule cells, although it is found in other forms on other endothelial cells. The addressin MAdCAM-1 is expressed on mucosal endothelium and guides entry into mucosal lymphoid tissue. The icon shown represents mouse MadCAM-1, which contains an IgA-like domain closest to the cell membrane; human MadCAM-1 has an elongated mucinlike domain and lacks the IgA-like domain. L-Selectin recognizes the carbohydrate moieties on the vascular addressins.

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current19:52, 10 March 2004 (15 KB)Tarek (talk | contribs)Janeway Figure 8.5. L-Selectin and the mucinlike vascular addressins direct naive lymphocyte homing to lymphoid tissues. L-Selectin is expressed on naive T cells, which bind to sulfated sialyl-Lewisx moieties on the vascular addressins CD34 and GlyCAM-1
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