File:Janeway-7.26.gif

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Janeway Figure 7.26. Replacement of light chains by receptor editing can rescue some self-reactive B cells by changing their antigen specificity. When a developing B cell expresses antigen receptors that are strongly cross-linked by multivalent self antigens such as MHC molecules on cell surfaces (top panel), the B cell undergoes developmental arrest. The cell lowers surface expression of IgM and does not turn off the RAG genes (second panel). Continued synthesis of RAG proteins allows the cell to continue light-chain gene rearrangement. This usually leads to a new productive rearrangement and expression of a new light chain, which combines with the previous heavy chain to form a new receptor (receptor editing; third panel). If this new receptor is not self-reactive, the cell is ‘rescued’ and continues normal development much like a cell that had never reacted with self (bottom right panel). If the cell remains self-reactive, it may be rescued by another cycle of rearrangement, but if it continues to react strongly with self it will undergo programmed cell death or apoptosis and be deleted from the repertoire (clonal deletion; bottom left panel).

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current20:09, 10 March 2004Thumbnail for version as of 20:09, 10 March 2004219 × 660 (26 KB)Tarek (talk | contribs)Janeway Figure 7.26. Replacement of light chains by receptor editing can rescue some self-reactive B cells by changing their antigen specificity. When a developing B cell expresses antigen receptors that are strongly cross-linked by multivalent self anti
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