File:Janeway-7.25.gif

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Janeway Figure 7.25. Binding to self molecules in the bone marrow can lead to the death or inactivation of immature B cells. Left panels: when developing B cells express receptors that recognize multivalent ligands, for example, ubiquitous self cell-surface molecules such as those of the MHC, they are deleted from the repertoire (clonal deletion). These B cells either undergo receptor editing, so that the self-reactive receptor specificity is deleted, or the cells themselves undergo programmed cell death or apoptosis. Center left panels: immature B cells that bind soluble self antigens able to cross-link the B-cell receptor are rendered unresponsive to the antigen (anergic) and bear little surface IgM. They migrate to the periphery where they express IgD but remain anergic; if in competition with other B cells in the periphery, they are rapidly lost. Center right panels: immature B cells that bind soluble self antigens with low affinity or that bind monovalent antigens do not receive any signal as a result of this interaction and mature normally to express both IgM and IgD at the cell surface. Such cells are potentially self-reactive, and they are said to be clonally ignorant as their ligand is present but is not able to activate them. Right panels: immature B cells that do not encounter antigen mature normally; they migrate from the bone marrow to the peripheral lymphoid tissues where they may become mature recirculating B cells bearing both IgM and IgD on their surface.

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current20:10, 10 March 2004Thumbnail for version as of 20:10, 10 March 2004461 × 385 (32 KB)Tarek (talk | contribs)Janeway Figure 7.25. Binding to self molecules in the bone marrow can lead to the death or inactivation of immature B cells. Left panels: when developing B cells express receptors that recognize multivalent ligands, for example, ubiquitous self cell-surf
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