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Janeway Figure 7.21. The rearrangement of T-cell receptor γ and δ genes in the mouse proceeds in waves of cells expressing different Vγ and Vδ gene segments. At about 2 weeks of gestation, the Cγ1 locus is expressed with its closest V gene (Vγ5; also known as Vγ3). After a few days Vγ5-bearing cells decline (upper panel) and are replaced by cells expressing the next most proximal gene, Vγ6. Both these rearranged γ chains are expressed with the same rearranged δ-chain gene, as shown in the lower panels, and there is little junctional diversity in either the Vγ or the Vδ chain. As a consequence, most of the γ:δ T cells produced in each of these early waves have the same specificity, although the antigen recognized in each case is not known. The Vγ5-bearing cells become established selectively in the epidermis, whereas the Vγ6-bearing cells become established in the epithelium of the reproductive tract. After birth, the α:β T-cell lineage becomes dominant and, although γ:δ T cells are still produced, they are a much more heterogeneous population, bearing receptors with a great deal of junctional diversity.

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current20:21, 10 March 2004 (25 KB)Tarek (talk | contribs)Janeway Figure 7.21. The rearrangement of T-cell receptor γ and δ genes in the mouse proceeds in waves of cells expressing different Vγ and Vδ gene segments. At about 2 weeks of gestation, the Cγ1 locus is expressed with its clos
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