File:Janeway-7.18.gif

From IKE
Jump to: navigation, search
Janeway-7.18.gif(463 × 518 pixels, file size: 38 KB, MIME type: image/gif)

Janeway Figure 7.18. The temporal expression of several cellular proteins known to be important for B-cell development. The proteins listed here are a selection of those known to be associated with early B-lineage development, and have been included because of their proven importance in the developmental sequence, largely on the basis of studies in mice. Their individual contributions to B-cell development are discussed in the text, with the exception of the Octamer Transcription Factor, Oct-2, which binds the octamer ATGCAAAT found in the heavy-chain promoter and elsewhere, and GATA-2, which is one example of the many transcription factors that are active in several hematopoietic lineages. The pax-5 gene product, known as B-lineage-specific activator protein (BSAP), is involved in regulating the expression of several of the other proteins listed. The tight temporal regulation of the expression of these proteins, and of the immunoglobulin genes themselves, would be expected to impose a strict sequence on the events of B-cell differentiation.

File history

Click on a date/time to view the file as it appeared at that time.

Date/TimeThumbnailDimensionsUserComment
current20:04, 10 March 2004Thumbnail for version as of 20:04, 10 March 2004463 × 518 (38 KB)Tarek (talk | contribs)Janeway Figure 7.18. The temporal expression of several cellular proteins known to be important for B-cell development. The proteins listed here are a selection of those known to be associated with early B-lineage development, and have been included beca
  • You cannot overwrite this file.

There are no pages that link to this file.