File:Janeway-7.14.gif

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Janeway Figure 7.14. The steps in immunoglobulin gene rearrangement at which cells can be lost. The developmental program usually rearranges the heavy-chain (H-chain) locus first and then the light-chain (L-chain) loci. Cells are allowed to progress to the next stage when a productive rearrangement has been achieved. Each rearrangement has about a one in three chance of being successful, but if the first attempt is nonproductive, development is suspended and there is a chance for one or more further attempts. The scope for repeated rearrangements is greater at the light-chain loci (see Fig. 7.16), so that fewer cells are lost between the pre-B and immature B cell stages than in the pro-B to pre-B transition.

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current20:03, 10 March 2004Thumbnail for version as of 20:03, 10 March 2004703 × 361 (23 KB)Tarek (talk | contribs)Janeway Figure 7.14. The steps in immunoglobulin gene rearrangement at which cells can be lost. The developmental program usually rearranges the heavy-chain (H-chain) locus first and then the light-chain (L-chain) loci. Cells are allowed to progress to t
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