Janeway Figure 5.10. The genetic organization of the major histocompatibility complex (MHC) in human and mouse. The organization of the principal MHC genes is shown for both humans (where the MHC is called HLA and is on chromo-some 6) and mice (in which the MHC is called H-2 and is on chromosome 17). The organization of the MHC genes is similar in both species. There are separate clusters of MHC class I genes (shown in red) and MHC class II genes (shown in yellow), although in the mouse an MHC class I gene (H-2K) appears to have translocated relative to the human MHC so that the class I region in mice is split in two. In both species there are three main class I genes, which are called HLA-A, -B, and -C in humans, and H2-K, -D, and -L in the mouse. The gene for β2-microglobulin, although it encodes part of the MHC class I molecule, is located on a different chromosome, chromosome 15 in humans and chromosome 2 in the mouse. The class II region includes the genes for the α and β chains of the antigen-presenting MHC class II molecules HLA-DR, -DP, and -DQ (H-2A and -E in the mouse). In addition, the genes for the TAP1:TAP2 peptide transporter, the LMP genes that encode proteasome subunits, the genes encoding the DMα and DMβ chains, the genes encoding the α and β chains of the DO molecule (DNα and DOβ, respectively), and the gene for tapasin (TAPBP) are also in the MHC class II region. The so-called class III genes encode various other proteins with functions in immunity (see Fig. 5.11).
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|current||19:45, 10 March 2004||(12 KB)||Tarek||Janeway Figure 5.10. The genetic organization of the major histocompatibility complex (MHC) in human and mouse. The organization of the principal MHC genes is shown for both humans (where the MHC is called HLA and is on chromo-some 6) and mice (in which|
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