Enzyme inhibition

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Enzyme inhibition is a feature in pharmacology in which an enzyme responsible for drug metabolism becomes incapable of doing its job sufficiently.

Competitive inhibition of the cytochrome P450 monooxygenase system is allegedly the most important form of drug inhibition. This type of inhibition is most likely to occur if a single P450 isozyme catalyzes a quantitatively important pathway for two chemicals taken together.

Some substrates covalently bind to an enzyme, irreversibly inhibiting its function. This is referred to as mechanism-based or suicide substrate inhibition.