Enzyme induction

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Enzyme induction is a process in drug metabolism in which a chemical or drug affects either the rate of degradation (reducing it) or the rate of synthesis (increasing it) of an enzyme — P450 in this case. This results in increased metabolism of the drug, which consequently decreases its efficacy. Induction is usually achieved upon repeated administration, and is accomplished by de novo synthesis of an enzyme protein, not by activation of an existing enzyme.

Induction can be isozyme selective (the most common) or isozyme specific.