Duodenal ulcer

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Duodenal ulcers are holes in the duodenum, usually resulting from acid hypersecretion, especially from the presence of Helicobacter pylori. Increased acid secretion from the stomach stimulates gastric metaplasia to occur in the duodenum as a response to the increased acid in the duodenum. This gastric epithelium in the duodenum may then become inflamed and ulcerated. Most duodenal ulcers occur in the first part of the duodenum.