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Dopamine is a substance that acts on dopaminergic receptors in the renal and splanchnic system. This drug also has beta adrenergic effects, and at larger doses is an alpha agonist. Dopamine does not cross the blood-brain barrier, meaning that intravenously-administered dopamine should have no neurologic effects despite the presence of dopamine receptors in the central nervous system. Clinically, dopamine is used to increase blood pressure and cardiac output in patients with shock.