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Diuretics are pharmacological agents that are used as global first line therapies against hypertension. They are used in the elderly and black people. They are relatively inexpensive, and help address volume-overloaded states.

These drugs exacerbate dyslipidemia, gout, hyperglycemia (and therefore type 2 diabetes), glucose intolerance, hypokalemia, and hypomagnesemia.

Thiazide diuretics can be combined with other antihypertensive agents, especially beta blockers, ACE inhibitors and angiotensin receptor blockers. Loop diuretics are poor antihypertensives except in patients with renal failure.