- All dimorphic fungi initially cause infection via inhalation except Sporothrix schenckii which goes via skin
- usually hands, forearms REMEMBER THIS ONE
- Causes ropey lymphadenopathy, especially inside of forearm
- Diagnosis without culture can be made if someone has 1-2 lesions like so with an history of gardening (especially if old rose bushes)
- General practitioners see these not uncommonly
- The spore is hardier and gets through a different route.
- Most infectious and invasive of ALL FUNGI!
- Causes San Joaquin Valley Fever (SVF)
- It is a kind of yeast form (arthroconidia)
- blown around in desert winds
- In Phoenix, many San Joaquin Valley Fever (SVF) cases seen after a windy weekend.
- Don't need many to get infected
- San Joaquin Valley Fever (SVF) - Endemic in the U.S., found in Africa and prevalent in Southwestern Ontario, especially London
- Usually thrown off by immunocompetent people
- Therefore, usually asymptomatic in most of the population.
- Immunodiffusion concept
- take bio fluid for analysis with antigen in it
- carefully overlay plates with fluid that can contain antibodies
- find the optimal concentration at which they form immune complexes
- endemic in Mississippi, Ohio, and the Great Lakes basin
- Resembles TB lesions (important note)
- Dimorphic fungi handout (DOC | PDF)