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  • A coenzyme is a prosthetic group (non-amino-acid) which, when bound to its apoenzyme, gives a holoenzyme.
  • Coenzymes have an essential role in many biochemical reactions in metabolism
  • Coenzymes often are co-substrates
    • the vitamin cofactor adds as an acceptor or donor of functional groups that are removed or added to the actual substrate
  • apoenzyme + coenzyme = holoenzyme