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Choledocholithiasis is the presence of gall stones in the common bile duct, which is a potentially serious problem that can lead to obstructive jaundice (increased bilirubin, alkaline phosphatase and GTP; normal aspartate transaminase (AST), amino alanine transferase (ALT)), an increased risk of cholangitis, and an increased risk of pancreatitis.

Possible sequelae include:

  1. The stone passes into the duodenum without effect
  2. Bile duct obstruction, usually partial and intermittent, caused by ball-valve action of the stone at the lower end of common bile duct
  3. Bile duct stricture due to fibrosis
  4. infection (cholangitis) by ascending intestinal bacteria
  5. Acute or chronic pancreatitis due to a stone wedged in or passing through the ampulla of Vater
  6. Prolonged obstruction leading to secondary biliary cirrhosis