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Bilirubin is an endogenous organic anion derived mainly from the degradation of hemoglobin. The continuous production of bilirubin within the body (300 mg/day in a normal male adult) provides a built-in "load test" of the efficiency of the hepatobiliary excretory pathways. When plasma levels of bilirubin and its conjugates total more than 35μmol/L, the yellow color may be seen in the eyes and skin - a condition termed jaundice.