Autoimmune hepatitis

From IKE
Jump to: navigation, search

Autoimmune hepatitis is a type of hepatitis that predominately affects middle aged females, usually with other autoimmune diseases (up to 60%). The diagnosis is confirmed in individuals with high positive antinuclear antibody (ANA) as well as anti-smooth muscle antibody (something about monkeys) coupled with a high fraction of IgG immunoglobulins. Diagnosis is important because autoimmune hepatitis usually responds to immunosuppression therapy, while other causes of chronic hepatitis do not.

Treatment is with prednisone and imuran, which result in immunosuppression and complete biochemical resolution.