Antiviral agent

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Antiviral agents are those agents that disrupt, or attempt to disrupt, the lifecycle of a virus. They include:

Special antiviral agents were developed to specifically deal with the HIV. Some are RT inhibitors, and include:

  • Nucleoside Analogs
    • Azidothymidine (AZT, Zidovudine, Retrovir)
    • Dideoxycytidine (ddC, Zalcitabine, Hivid)
    • 3TC (2'-deoxy-3'-thiacytidine, Lamivudine, Epivir)
    • Dideoxyinosine (ddI, Didanosine, Videx) (not important)
    • d4T
  • Non-nucleoside Analogs
    • Delavirdine - new
    • Nevirapine - new

Others are inhibitors of HIV Protease:

  • Indinavir Sulphate (Crixivan)
  • Saquinavir mesylate (Inverase) (mesylate = methanesulfonate)
  • Nelfinavir - new
  • Ritonavir - new

Anti-HIV Cocktails: - use one or two RT inhibitors with a protease inhibitor - clinically used combinations: - Crixivan and 3TC alone did not work well - AZT, 3TC and Crixivan - Best results to date - AZT, ddI, and Crixivan also tried - side effect - nausea and vomiting, headache