Angiosarcoma

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Angiosarcomas are the most common sarcomas (endothelial in origin) arising in the liver, and are very rare. They are highly aggressive and rarely resectable, with a very poor prognosis. There is a history of exposure in 40% of cases to known risk factors, which are thorotrast (a radioactive contrast agent used in the 20s - 50s), vinyl chloride (PVC manufacturing), chronic arsenic intake and sex steroids. Elderly males are usually affected.