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Amniocentesis is a technique or fetal screening in the reproductive female during pregnancy, usually as a follow-up test to confirm a diagnosis of the fetus in patients with positive maternal serum screening or integrated prenatal screen, as well as women with an advanced maternal age of more than 35 years old. In this procedure, amniotic fluid is withdrawn through the maternal abdomen between 15 and 17 weeks gestation [1].

α-fetoprotein (AFP) and bilirubin levels are assessed. The risk to the fetus is approximately 0.5% over and above the background fetal loss rate of 3.0%.